Abstract
Malignant mesothelioma of the pericardium is a rare and fatal condition that clinicians should be aware of due to its variability of clinical manifestation. The diagnosis may be delayed as a result of delayed treatment. Here, we report two cases of malignant pericardial mesothelioma with two different clinical aspects: cardiac tamponade and mimic tuberculous pericarditis. Both patients: may have indirect exposure to asbestos. Despite chemotherapy, both patients died at 2 weeks and 3 months after the diagnosis. Malignant mesothelioma of the pericardium is fatal, has a variety of presentation, and may not be related to asbestosis exposure.
Highlights
Malignant pericardial mesothelioma is extremely rare and has poor prognosis. It accounted for only 0.3% of mesothelioma death worldwide [1]
Patients usually present with dyspnea on exertion caused by pericardial effusion or heart failure
Pemetrexed is a third generation antifolate drug. It is a promising agent often used with cisplatin or carboplatin to treat pleural mesothelioma since the combination improved progression-free and overall survival significantly
Summary
Malignant pericardial mesothelioma is extremely rare and has poor prognosis. It accounted for only 0.3% of mesothelioma death worldwide [1]. The relationship between asbestos and this lethal tumor is unclear [2]. Patients usually present with dyspnea on exertion caused by pericardial effusion or heart failure. The characters of pericardial effusion, may be different such as cardiac tamponade or constrictive pericarditis [3]. We reported two patients diagnosed as pericardial malignant mesothelioma with two different presentations
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