Abstract
Primary malignant melanoma of the vagina is an extremely rare variant of melanoma that accounts for <3% of all vaginal malignancies. Primary malignant melanoma of the vagina has a worse prognosis as compared with non-genital melanomas or other vaginal malignant neoplasms. A-35-year-old female had a diagnosis of primary malignant melanoma of the vagina. A local excision of the tumor was first performed, followed by a radical excision as a further therapeutic measure. The patient returned after three weeks, presenting with a vesico-vaginal fistula. A conservative operation was subsequently performed in order to improve the quality of life of the patient. Pelvic metastases were identified 6 months after the completion of the last surgical therapy and subsequent follow-up examinations were performed in another hospital. The present case study describes the clinical features and surgical procedures of this patient with primary malignant melanoma of the vagina. In conclusion, melanoma of the vagina is an extremely aggressive cancer and the overall prognosis is poor despite the various treatment options.
Highlights
Malignant melanoma is considered to arise from melanocytic cells in the skin and mucosal membranes
The present study describes a case of vaginal melanoma and a discussion of the treatment options
Primary malignant melanoma of the vagina is a rare gynecological malignancy that is associated with high risk of recurrence, distant metastases and a short survival time [5]
Summary
The patient was clinically diagnosed with a cyst of vagina, and a tumor resection of vaginal wall was performed. Further pathological analyses of the specimen confirmed that the tumor was a primary vaginal melanoma. One. CHEN et al: CASE REPORT FOR MALIGNANT MELANOMA OF THE VAGINA month after the local excision, the patient presented at Cancer Center of Sun Yat-Sen University (Guangzhou, China) for further therapy. Histopathological results of the specimen revealed the entire vaginal wall was involved, no tumor tissue was present in the surgical margins, and no lymphatic invasion was identified. The general condition of the patient rapidly deteriorated and two months following the surgery, a gynecological examination revealed a pelvic metastasis. Six months following the surgery, the patient had difficulties in deffacating, and a CT scan indicated the mass had covered the entire pelvic cavity.
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