Abstract
This paper concerns a case of Malignant Fibrous Histiocytoma (MFH) of the Breast in a 73-years-old woman. A lump was found in her right breast, measuring 1.7 cm in diameter. Surgical excision followed, and pathology revealed a highly atypical spindle cell tumor. Immunohistochemistry along the histological features, excluded the possibility of carcinoma, malignant phyllodes tumor, or another type of pure sarcoma. There was no history of previous irradiation in the region. MFH is among the rarest types of sarcoma of the breast, and most of the times behaves aggressively. Excision with wide, free-of-tumor margins is the most effective treatment, when feasible.
Highlights
The most common malignant tumor of the breast is by far the invasive carcinoma of the ductal or lobular type
The frequency of breast sarcomas in total is less than 1% of all the malignant tumors of the breast [1, 2]
All of the above antibodies presented a negative reaction in the tumor cells, except CD68 (Figure 3) and vimentin
Summary
The most common malignant tumor of the breast is by far the invasive carcinoma of the ductal or lobular type. Pure sarcomas could be angiosarcomas, osteosarcomas, liposarcomas, leiomyosarcomas, fibrosarcomas, rhabdomyosarcomas, dermatofibrosarcomas protuberans or malignant fibrous histiocytomas [3, 4]. Among them angiosarcoma is known to be the most frequent sarcoma type of the breast, while malignant fibrous histiocytoma (MFH) seems to be one of the rarer types. The present case concerned a white female, 73 years old. On mammography the tumor was 1.7 cm in diameter and appeared as relatively circumscribed lesion. She was operated upon for this lump, and she had intraoperative frozen sections. The latter revealed a high-grade malignant tumor. The following antibodies were used: broad spectrum keratins (clone: AE1/AE3, dilution 1 : 50, Dako, Glostrup, Denmark), desmin (clone: es-der, dilution 1 : 100, Newcastle upon Tyne, UK), a-smooth muscle actin (clone: asm, dilution 1 : 50, Novocastra), CD34 (clone: Qbend, dilution 1 : 50, Dako), S-100 protein (clone: pol, dilution 1 : 400, Dako), CD68 (clone: KP-1, dilution 1 : 100, Dako), vimentin (clone: V9, dilution 1 : 100, Novocastra), estrogen receptor (clone: GF11, dilution 1 : 40, Novocastra), progesterone receptor
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