Abstract
Background: MCI is caused by occlusion of the middle cerebral artery (MCA) or internal carotid artery. Causing large ischemias, which edema can exert a mass effect, usually between the 2nd and 5th day, resulting in intracranial hypertension, herniation and even death. Objective: Review data related to the benefits of DC, elucidating the procedure, prognosis and indications of the method. Method: Review on MEDLINE and PubMed platforms. The descriptors: “craniectomy” AND “malignant infarction”. Were selected 9 articles dated between 2016 and 2021. Results: MCI has some clinical (Youngs, NIHSS>15, neurological deterioration) and radiological predictors (Impairment> 50% of the ACM territory, midline deviation> 5mm, MRI with DWI> 145 cm3). These patient’s clinical aim is to reduce intracranial pressure (ICP), however, as a consequence of the worse prognosis in clinical therapy, there’s a possibility of intervention by DC, which is a surgical technique that relieves ICP and prevents secondary injuries. It reduces the mortality rate and increases the patient’s survival up 3x compared to clinical management, but at the expense of low quality of life. Patients ≤60 years with loss of consciousness, must have an indication for DC within 48 hours after ictus. The indication should be better evaluated and a thorough discussion with family members. Conclusion: DC minimizes injuries and the risk of herniation. However, despite decreasing mortality, it can lead to complications and poor prognosis, although it isn’t uncommon the indication for the procedure and an approach to palliative care.
Highlights
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack
The present review study aimed to address the mechanisms of action of capsaicin and other chemical inducers in mast cell degranulation and an interaction of nerves and events that happen in the dura mater with the activation of mast cells
Conclusion: the analyzed data indicate that the polymorphisms contributed to the susceptibility to Parkinson’s disease (PD), further studies related to the polymorphisms and their relationship to PD are still needed for more ethnic groups, and early diagnosis is possible
Summary
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack. Methods: A literature review and an observational, descriptive and transversal data collect on treatment for acute demyelinating polyradiculoneuritis, available at DATASUS from January 2008 to December 2020, and articles available at Scielo and PubMed. Results: There were 7,917 hospitalizations, representing a total expenditure of R$ 9,392,552.04, 2009 being the year with the highest number of hospitalizations (809) and 2017 with the highest amount spent during the period (R$ 967,284.65). Methods: A literature review and an observational, descriptive and transversal data collect on surgical treatment was carried out, available from January 2008 to December 2020 and articles available in Scielo, Lilacs and PubMed. Results: There were 15,148 hospitalizations for surgical procedures for the treatment of chronic subdural hematoma, representing a total expenditure of R$ 45,365,258.21, with 2018 being the year with the highest number of hospitalizations (1,418) and with the highest amount spent during the period (R$ 4,570,334.28). Conclusions: The “Coca-Cola Bottle sign” is a classic sign of Graves’ disease, some signs, such as, unilateral and single orbital musculature involvement, may be suggestive of involvement by other etiologies, suggesting the benefit of an early expanded investigation
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