Abstract
Anti-NMDA-Receptor encephalitis is a severe form of encephalitis that was recently identified in the context of acute neuropsychiatric presentation. Here, we describe the case of a 17-year-old girl referred for an acute mania with psychotic features and a clinical picture deteriorated to a catatonic state. Positive diagnosis of anti-NMDA-receptor encephalitis suggested specific treatment. She improved after plasma exchange and immunosuppressive therapy. Post-cognitive sequelae (memory impairment) disappeared within 2-year follow-up and intensive cognitive rehabilitation.
Highlights
NMDA receptors are ligand-gated cation channels that play an important role in synaptic plasticity [1] and seem to be implicated in the physiopathology of neuropsychiatric disorders [2]
We present a case report of a 17-yearold girl referred for acute mania with psychotic features and malignant catatonia due to anti-NMDA-Receptor encephalitis
Postcognitive sequelae disappeared within 2 years. She was able to return to school and seemed to have regained her original cognitive abilities (Table 1). In this case report, acute mania with psychotic features deteriorating to catatonic state revealed anti-NMDA-receptor encephalitis
Summary
NMDA receptors are ligand-gated cation channels that play an important role in synaptic plasticity [1] and seem to be implicated in the physiopathology of neuropsychiatric disorders [2]. Several case reports of anti-NMDA-receptor encephalitis have been published, suggesting that this illness is not rare [4,7,8,9,10,11]. Published a series of 100 cases of anti-NMDA-Receptor encephalitis [12]. The same group reported on more than 400 patients with anti-NMDA-Receptor
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