Malignant blue naevus of the scalp

Abstract

cancer-cell growth by the peroxisome proliferator-activated receptorgamma agonists through induction of apoptosis. Biochem Biophys Res Commun 2000; 270: 400–05. 74 Sasaki H, Tanahashi M, Yukiue H, et al. Decreased perioxisome proliferator-activated receptor gamma gene expression was correlated with poor prognosis in patients with lung cancer. Lung Cancer 2002; 36: 71–76. 75 Han SW, Greene ME, Pitts J, et al. Novel expression and function of peroxisome proliferator-activated receptor gamma (PPARgamma) in human neuroblastoma cells. Clin Cancer Res 2001; 7: 98–104. 76 Rohn TT, Wong SM, Cotman CW, Cribbs DH. 15-deoxy-delta12,14prostaglandin J2, a specific ligand for peroxisome proliferatoractivated receptor-gamma, induces neuronal apoptosis. Neuroreport 2001; 12: 839–43. 77 Burdge GC, Rodway H, Kohler JA, Lillycrop KA. Effect of fatty-acid supplementation on growth and differentiation of human IMR-32 neuroblastoma cells in vitro. J Cell Biochem 2000; 80: 266–73. 78 Berge K, Tronstad KJ, Flindt EN, et al. Tetradecylthioacetic acid inhibits growth of rat glioma cells ex vivo and in vivo via PPARdependent and PPAR-independent pathways. Carcinogenesis 2001; 22: 1747–55. 79 Kato M, Nagaya T, Fujieda M, et al. Expression of PPARgamma and its ligand-dependent growth inhibition in human brain tumor cell lines. Jpn J Cancer Res 2002; 93: 660–66. 80 Zhou XP, Smith WM, Gimm O, et al. Overrepresentation of PPARgamma sequence variants in sporadic cases of glioblastoma multiforme: preliminary evidence for common low-penetrance modifiers for brain-tumour risk in the general population. J Med Genet 2000; 37: 410–14. Review PPAR in cancer therapy