Abstract
BackgroundMalignant acrospiroma is a rare tumor of the eccrine sweat glands accounting for around 6% of all malignant eccrine tumors. Typically, it presents as large ulcerated nodules, and diagnosis can be challenging as it has great overlap with its benign counterpart.Case presentationWe herein report a case of acral malignant acrospiroma, initially treated with surgical excision and adjuvant radiotherapy. After metastatic disease was confirmed, subject received multiple lines of chemo- as well as targeted therapy. Genomic testing was also done using next generation sequencing.ConclusionTo the best of our knowledge, this is the first case of acral malignant acrospiroma with reported next generation sequencing results.
Highlights
Malignant acrospiroma is a rare tumor of the eccrine sweat glands accounting for around 6% of all malignant eccrine tumors
Malignant acrospiromas arise from the intradermal duct of eccrine sweat glands and account for approximately 6% of malignant eccrine tumors [1] compared to their more prevalent benign counterparts [2]
They appear in the literature under multiple nomenclatures, including clear cell hidradenocarcinoma, malignant clear cell hidradenoma, and malignant hidradenoma [3, 4]
Summary
Malignant acrospiroma is a rare tumor of the eccrine sweat glands accounting for around 6% of all malignant eccrine tumors. We report a case of acral malignant acrospiroma initially treated with surgical excision and adjuvant radiotherapy. We tested the tumor for genomic alterations using generation sequencing. Case presentation A 73-year-old White male was referred to our institution for the treatment of metastatic malignant acrospiroma.
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