Abstract
Objective: to analyze the association between the use of agrochemicals and congenital malformations in municipalities with greater exposure, as well as to evaluate the nature of the correlation between the trend observed and the volume of agrochemicals considered as endocrine disruptors in the state of Minas Gerais, Brazil, between 1994 and 2014. Model Study: Cross-sectional study, exploratory, descriptive and quantitative character. Method: Rates of malformations for the periods 1994-2003 and 2004-2014 were calculated from the information on live births available at SINASC/Ministry of Health. Odds Ratio tested the association between types of malformations and variables for each variable separately. The significance was set at p<0.05. Results: there was an increasing trend in the rates of congenital malformation in the state of Minas Gerais, especially at Triângulo Mineiro/Alto Paraíba and Vale do Mucuri/Jequitinhonha regions. It was found that the rates for congenital malformations were higher for the years of greatest exposure (2004-2014) and had a statistically significant association for all congenital malformations in the state of Minas Gerais. Conclusion: Maternal exposure to pesticides was related with higher incidence of congenital malformations.
Highlights
Objective: to analyze the association between the use of agrochemicals and congenital malformations in municipalities with greater exposure, as well as to evaluate the nature of the correlation between the trend observed and the volume of agrochemicals considered as endocrine disruptors in the state of Minas Gerais, Brazil, between 1994 and 2014
It was found that the rates for congenital malformations were higher for the years of greatest exposure (2004-2014) and had a statistically significant association for all congenital malformations in the state of Minas Gerais
Maternal exposure to pesticides was related with higher incidence of congenital malformations
Summary
Malformações congênitas em regiões de monocultivo no estado de Minas Gerais, Brasil. RESUMO Objetivo: analisar a associação entre o uso de agrotóxicos e as malformações congênitas em municípios com maior exposição, assim como avaliar a natureza da correlação existente entre a tendência observada e o volume de agrotóxicos considerados como disruptores endócrinos no estado de Minas Gerais, Brasil, entre 1994 e 2014. Resultados: houve uma tendência crescente nas taxas de malformação congênita no estado de Minas Gerais, com destaque às regiões do Triângulo Mineiro/ Alto Paraíba e Vale do Mucuri/Jequitinhonha. Constatou-se que as taxas referentes às malformações congênitas foram maiores para os anos de maior exposição (2004-2014) e tiveram associação estatisticamente significativa para todas as malformações congênitas no estado de Minas Gerais. Conclusão: A exposição materna aos agrotóxicos foi relacionada à maior ocorrência de malformações congênitas.
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