Abstract
399 fertile men in 16 countries voluntarily received weekly injections of testosterone for up to 18 months so researchers could examine the effectiveness of this testosterone depot at preventing pregnancy. The contraceptive was able to achieve a sperm count below the threshold of fertility at 52 days on average. Eight men could not reach the threshold and were excluded from the study. 42 other men dropped out. Men from Oriental countries were more likely to achieve azoospermia than Western men (95% vs. 68%). 11 pregnancies occurred all of which involved men with a low sperm count (<or= 3 million/ml). Among men with a low sperm count the pregnancy rate was 1.4% which is better than that for current methods of reversible male contraception. Side effects were rare and were mainly limited to mood changes and acne. The participation of the men in the study demonstrated that they can be as committed to family planning as women.
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