Abstract

This chapter describes the basic technology and application of matrix-assisted laser desorption ionization (MALDI) imaging mass spectrometry (MS) in the field of neurobiology. Examples of applications that search for biomarkers of diseases of the central nervous system for both diagnostic and prognostic purposes are discussed. Newly developed strategies and analytical methods are discussed for the study of drug pharmacokinetics, neuropeptide metabolism, and treatment-induced or disease-specific effects on the proteome.

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