Abstract
Background Non-small-cell lung carcinoma (abbreviated as NSCLC) progresses rapidly and lacks appropriate biological markers. Recent studies have shown that long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) has potential application value for clinically diagnosing lung carcinoma. Thus, this study conducted a systematic review and meta-analysis for assessing if MALAT-1 has a relationship to NSCLC outcome. Methods This study conducted the search of China National Knowledge Infrastructure, China Science and Technology Journal, SinoMed, EMBASE, Cochrane library, Web of Science, Wanfang database, and PubMed from inception to September, 1, 2021. The published article about MALAT-l expression for NSCLC patients was analyzed. We used combined hazard rates under the confidence interval of 95% for examining the relationship of MALAT-l and NSCLC.Results In this meta-analysis, we found that 10 studies were included, and MALAT-1 expressions were distinctly related to an unfavorable overall survival (HR: 2.34 (1.65, 3.33); I2 = 76%). Considering the merger's clinical heterogeneity, for meta-analysis, we used the random-effects method. Conclusion Overexpression of MALAT-1 showed correlations to the less effective outcome of NSCLC. MALAT-1 might be a new NSCLC prognosis marker.
Highlights
Lung carcinoma is a highly common carcinoma with high mortality, in accordance with the latest data released by the World Health Organization’s International Agency for Research on Carcinoma in 2020 [1]
The inclusion standards are as follows: (1) all the patients were diagnosed as non-smallcell lung carcinoma (NSCLC); (2) the research content is about the application or evaluation of circulating metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) in the diagnosis of lung carcinoma; (3) the study needs to provide sufficient diagnostic indexes to meet the data extraction and statistical investigation; (4) using quantitative PCR to present MALAT-1 expression with NSCLC patients; and (5) researches assessed the correlations of overall survival
In order to assess the correlation between MALAT-1 and survival time of cases, an in situ hybridization was performed in 352 cases of non-small-cell lung carcinoma
Summary
Non-small-cell lung carcinoma (abbreviated as NSCLC) progresses rapidly and lacks appropriate biological markers. This study conducted a systematic review and metaanalysis for assessing if MALAT-1 has a relationship to NSCLC outcome. The published article about MALAT-l expression for NSCLC patients was analyzed. We used combined hazard rates under the confidence interval of 95% for examining the relationship of MALAT-l and NSCLC.Results. In this meta-analysis, we found that 10 studies were included, and MALAT-1 expressions were distinctly related to an unfavorable overall survival (HR: 2.34 (1.65, 3.33); I2 = 76%). Considering the merger’s clinical heterogeneity, for meta-analysis, we used the random-effects method. Overexpression of MALAT-1 showed correlations to the less effective outcome of NSCLC.
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