Abstract
This chapter presents the studies of the effect of anti malarial chemoprophylaxis on the serum protein concentration of African infants suggested that exposure to malaria was associated with an increase in the serum gamma globulin concentration. The subsequent demonstration of the effectiveness of gamma globulin fractions of immune African sera in the therapeutic treatment of severe clinical cases of falciparum malaria confirmed the view that the increased gamma globulin concentration of Africans living in a holoendemic malarious area was associated with an acquired resistance to the infection. The sera of the children were first titrated for fluorescent antibody activity against two geographical strains of P. falciparum and P. vivax, their serum gamma globulin concentration subsequently determined. A definite gradation of increasing fluorescent antibody activity with age was associated with increasing concentration of the serum gamma globulin. Correspondingly, the mean albumin concentration of the older children was significantly lower than that of the infants.
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