Abstract
Evaluation of: Bejon P, Lusingu J, Olotu A et al. Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age. N. Engl. J. Med. 359(24), 2521–2532 (2008).Since the pioneer studies performed by Nussengweig, Vanderberg, Most and Orton on vaccination with irradiated Plasmodium sporozoites, many attempts have been carried out to develop an effective human malaria vaccine. The understanding of the immune mechanisms underlying the protection induced by irradiated sporozoites paves the way to the development of subunit vaccines, such as RTS,S. To date, this vaccine, in combination with an effective adjuvant therapy, is the only one to demonstrate protection in man in artificial challenge as well as in natural field trials. It has been established that this vaccine is capable of eliciting high antibody titers along with strong cell-mediated immunity, which both contribute to the efficacy of the vaccine. The paper under evaluation confirms RTS,S/AS01E as a very promising candidate malaria vaccine against Plasmodium falciparum infection in young infants living in a malaria endemic transmission area.
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