Abstract
WE KNOW THAT man acts as the normal host for four species of human malaria:Plasmodium vivax, P falciparum, P malariae, andP ovale. The possibility of nonhuman reservoirs was not seriously considered until Eyles et al1demonstrated a fifth species ofPlasmodiumtransmissible to man, the B strain ofP cynomolgi, normally a parasite of monkeys. Four accidental infections by this simian malaria occurred amongst laboratory workers in the US between April and July of 1960, making it apparent that the B strain ofP cynomolgiwas capable of producing malaria in man.2 Initial studies with inmate volunteers infected with this parasite were carried out by Dr. Henry Beye and his associates3at the US Federal Penitentiary in Atlanta, with emphasis placed on clinical and parasitological observations. Additional clinical and physiological responses in inmate volunteers infected with this B strain ofP cynomolgiand the comparison
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