Abstract
Maladaptive Plasticity and Neuropathic Pain.
Highlights
Low back pain affects a large number of patients
Han et al evaluate the analgesic effects of a novel synthesized nitronyl (NIT) nitroxide radicals on radicular low back pain in a rat model generated by chronic dorsal root ganglia (DRG) compression
Activating transcription factor 3 (ATF3) and CGRP are upregulated in bilateral DRG neurons and may contribute to the expression of DRG compression-induced pain
Summary
Low back pain affects a large number of patients. Deformation of DRGs and their nerve roots is implicated in the pathogenesis. The activation of TRPV1 in the terminal of nociceptive primary afferents conveys noxious information to the spinal cord and superspinal regions. Recent studies identified critical roles of TRPV1 in the central regions of pain pathway in pain regulation.
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