Malabsorption Syndrome Due to Tropheryma Whipplei Severe Infection in a Patient Thirteen Years after Kidney Transplantation

Abdellaoui I,Sahtout W,Ben Mansour I

doi:10.4172/2161-0959.1000272

Abstract

Whipple's disease (WD) is a rare chronic and multi-systemic infectious illness. The exposing factor to WD is an underlying genetic predisposition that leads to colonization of T. whipplei throughout the intestinal tract. Here, we report the first case of WD, to our knowledge, with typical systemic and gastrointestinal manifestations, malabsorption syndrome and serious alteration leading to death in a kidney transplant recipient. We intend to describe its clinical presentation, the methods for its diagnosis, and the outcome of treatment. It's a 27-year-old man without history of arthritis or diarrheal illness. He received a cadaveric graft in 23/12/1999 at the age of fifteen. His HLA analysis was A1 A33 B14 B35 BRB1*01 DRB1*11. The recipient lived in an urban environment without well water or animals. Five years after transplantation, he complained of diarrhoea and fever with a negative infectious work up. These gastrointestinal symptoms were resolved after empiric antibiotics. The recipient was hospitalized in 2012, thirteen years after transplantation, to explore a second episode of chronic afebrile diarrhoea with loss of weight and worsening of the graft function. Labs showed malabsorption syndrome, anaemia and leukopenia but no inflammatory signs. Anti-gliadine and anti-transglutaminase antibodies were negative. Bacteriological and parasitological stools tests as well as blood cultures were negative. Cytomegalovirus antigenemia and tumor markers were also negative. The patient has not been treated with antibiotics for WD and MMF toxicity was more likely to be responsible of the malabsorption syndrome. The mycophenolate mofetil was switched to Azathioprine. In October 2015, he was hospitalized for fever, diarrhoea and arthralgia without arthritis, hypokalemia, dehydration, important loss of weight and worsening of the graft function. The endoscopic exploration showed erythematous antral mucosa, severe gastritis and duodenal lymphangiectasia. Biopsies showed atrophied villi, abraded epithelium and filled villi axis with foamy macrophages strongly stained in PAS coloration. This histologic aspect is typically suggestive of T. whipplei intestinal infection. Sixteen years after transplantation, the patient was dead after two days in the intensive care unit. The diagnosis of WD was certain based on clinical and histopathological proofs.

Highlights

Whipple’s disease (WD) is a rare chronic and multisystemic infectious illness
The exposing factor to WD is an underlying genetic predisposition that leads to colonization of T. whipplei throughout the intestinal tract, lymphoreticular system, and central nervous system
We report the first case of WD, to our knowledge, with typical systemic and gastrointestinal manifestations, malabsorption syndrome and serious alteration leading to death in a kidney transplant recipient

Summary

Introduction

Whipple’s disease (WD) is a rare chronic and multisystemic infectious illness. WD was first described in 1907 the Tropheryma whipplei, a gram positive intracellular bacillus of the phylum actinobacteria, was successfully cultured in 2000 [1,2,3]. The diagnosis of WD is suggested by duodenal biopsy when histology shows periodic acid-Schiff (PAS)-positive foamy macrophages, and can be confirmed by T. He complained of diarrhea and fever with a negative infectious work up These gastrointestinal symptoms were resolved after empiric antibiotics. The recipient was hospitalized in 2012, thirteen years after transplantation, to explore a second episode of chronic afebrile diarrhea with loss of weight and worsening of the graft function. The patient was deceased after two days in the intensive care unit (ICU) from a heart arrest due to arrhythmia It was most probably caused by the severe hypokalemia despite central intravenous treatment (figure 2). The diagnosis of WD was certain based on clinical and histopathological proofs (figure 3)

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