Abstract
Calorie restriction enhances longevity in many organisms. In yeast, this response involves Sir2, a histone deacetylase. It has not been clear if Sir2 is directly activated by nicotinamide adenine dinucleotide (NAD + ), or if depletion of the Sir2 inhibitor nicotinamide is responsible for its apparent activation. Using in vivo nuclear magnetic resonance spectroscopy to quantify levels of total free NAD + in cells, Anderson et al. observed that calorie restriction reduced cellular NAD + levels in yeast. These results suggest that food deprivation does not activate Sir2 by increasing the availability of this small molecule. R. M. Anderson, M. Latorre-Esteves, A. R. Neves, S. Lavu, O. Medvedik, C. Taylor, K. T. Howitz, H. Santos, D. A. Sinclair, Yeast life-span extension by calorie restriction is independent of NAD fluctuation. Science 302 , 2124-2126 (2003). [Abstract] [Full Text]
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