Abstract
Electrodiagnostic (EDx) testing consists of a nerve conduction study and needle electromyography (EMG), as these tools are very useful in localizing causes of neuromuscular weakness. EDx testing is especially helpful in confirming a suspected clinical diagnosis of myopathy with myopathic EMG changes strongly associated with positive findings on muscle biopsy. Furthermore, EDx features of a fibrotic muscle predict sites that should be avoided for biopsy. In all forms of inflammatory and necrotizing myopathy, affected muscles typically exhibit fibrillation potentials or positive sharp waves and short-duration, low-amplitude, polyphasic motor unit potentials. In chronic myopathies, especially inclusion body myositis, there may also be a subpopulation of high-amplitude, long-duration, motor unit potentials. EDx is sensitive for detecting myopathy, but non-specific in identifying the cause for the myopathy.
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