Abstract
The Zero Childhood Cancer Precision Medicine Program (ZERO), a joint initiative of Children’s Cancer Institute, and Kids Cancer Centre, Sydney Children’s Hospital, Randwick, integrates whole genome sequencing, transcriptome sequencing (RNA-seq) and methylation array to provide an integrated multi-omics pipeline, aiming to improve treatment outcomes for high-risk paediatric cancer patients (<30% survival). Unique to ZERO, we have developed a comprehensive RNA-seq pipeline to accurately identify molecular aberrations, infer their predicted function and pathogenicity, and identify aberrantly expressed genes.
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