Making sense (and antisense) of myosin heavy chain gene expression. Comments on “Intergenic bidirectional promoter and cooperative regulation of the IIx and IIb MHC genes in fast skeletal muscle” by Rinaldi et al.

Abstract

for over 40 years, our primary understanding of how eukaryotic gene transcription is regulated has centered on the promoter concept. In this model, transcriptional activators bind to consensus sequences in the proximal upstream regulatory region of a gene, altering chromatin structure to allow