Abstract
In Vitro Tumor Models The success of personalized cancer therapy hinges on a timely clinical decision and a preclinical model that can recapitulate tumor and stromal heterogeneity for clinically relevant drug profiling. In article 2202279, Eliza Li Shan Fong and co-workers review how by transcending the existential reductionist approaches, bioengineered patient-derived explant (PDE) models can truly replicate the tumor features in vivo and allow clinicians to rapidly offer and strategize specific care and treatment for each cancer patient.
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