Making and assessing 3D dosimeters

Abstract

Several 3D dosimeters are commercially available. However, there are many circumstances that require a customized 3D dosimeter. Examples include feasibility tests of non-standard treatment modalities, inhomogeneous tissue configurations, unique shapes and sizes and teaching. In this session, general approaches for preparing radiochromic dosimeters, Fricke and polymer gel dosimeters, micelle gel and silicone dosimeters were presented. Advise will be given to developers of new 3D dosimeters. For optical readout, light absorption and scatter can limit the practical size of dosimeters. Specifically, increasing from 5 to 15 cm diameter dosimeters is optically challenging. Strategies to maximize initial optical transmission were presented. For MRI readout, the dose resolution is determined by both the dosimeter sensitivity and the pulse sequence parameters and the accuracy is determined by the sensitivity of the dosimeter to temperature and dose rate, next to imaging performance. For X-ray CT imaging, the dose resolution is determined by the sensitivity of the dosimeter which largely depends on the polymer density that can be achieved. The importance of characterizing the dosimeter in terms of dose sensitivity and stability, spatial integrity, dose rate and fractionation dependence, oxygen and ambient light sensitivity, temperature sensitivity and thermal history were emphasized. The dosimeter requirements also dictate the types of vessels and scanners appropriate for readout. For example, the preferred dosimeter formulation may include a compound that is incompatible with the preferred vessel.