Abstract

Introduction : The increase in Candida infections, associated with several degrees of immunodeficiency, increased the prescription of antifungal treatments, which favored the emergence of resistant strains. New antifungal agents have been supplied by plants. Purpose: In this study, anti- Candida activity of P. graveolens was evaluated because of its anti-inflammatory, atimicrobial, antifungal and antioxidant properties reported in folk medicine. Methods : The strains tested were Candida albicans ATCC 5314, C. glabrata ATCC 2001, C. parapsilosis ATCC 22019, C. krusei ATCC 6258 and C. tropicalis ATCC 13803. Resazurin-based 96-well plate microdilution method was used for the determination of Minimum Inhibitory Concentration (MIC) of geraniol and linalool, the major constituents from P. graveolens essential oils. The concentrations tested ranged from 3.9 to 1000 µg/mL. Results: Geraniol was the most effective test substance, exhibiting an MIC of 37.5 µg/mL against C. parapsilosis . The Candida strais were scaled from the highest to the lowest sensitive to geraniol as C. parapsilosis > C. glabrata > C. krusei ~ C. tropicalis > C. albicans . Linalool showed to be effective against C. parapsilosis in the concentration of 125 µg/mL. Conclusion : Our results contribute to studies that search new antifungal agents for the treatment of candidiasis, reverting benefits to the population and building alliances between education and health.

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