Major plasma lipids and fatty acids in four HDL mammals

Abstract

Lipid classes and their fatty acids were compared in plasma from four mammals: a laboratory rodent, the mouse; two domestic animals, the cat and dog; and a wild animal, the South American armadillo, Chaetophractus villosus. In all, the most abundant lipoprotein was high-density lipoprotein (HDL). In the total lipid of plasma, phospholipids (PL) predominated in all four species, in correlation with the proportion of HDL, both being largest in dogs. The major PL was phosphatidylcholine (PC), followed by sphingomyelin (SM) and lysophosphatidylcholine. The total plasma lipid from the four species contained long-chain n-6 polyunsaturated fatty acids as the predominant acyl groups, followed by comparable proportions of total saturated and monoenoic fatty acids and small percentages of n-3 PUFA. The percentages of these four major groups of fatty acids in PC, SM, triacylglycerols and cholesterol esters were similar among species, but showed significant differences in the ratios between major individual fatty acids composing these groups.