Abstract
A single immunisation of DA (RTI av1) rats with spinal cord homogenate (SC) emulsified in CFA (complete Freund's adjuvant) or the minor myelin component myelin oligodendrocyte glycoprotein (MOG) in CFA results in experimental autoimmune encephalomyelitis (EAE) with a relapsing/remitting disease course and a histopathology closely resembling multiple sclerosis. 1,2 This article shows that major histocompatibility complex (MHC) congenic LEW.1AV1 (RTI av1) rats develop a relapsing/remitting paraparesis similar to DA rats after single immunisations with either SC+CFA or rMOG+CFA. The PVG (RTI c) rat is considered resistant to EAE . 3 Nevertheless, we were able to induce a brief monophasic EAE in PVG rats by immunisation with an encephalitogenic peptide derived from myelin basic protein (MBP 63–88+CFA). 4 The severity of disease was greatly enhanced in MHC congenic PVG-RT1 a (RTI av1) rats, but the disease course was still monophasic. Our observations imply that induction of a relapsing/remitting disease course in EAE requires a combination of correct MHC haplotype and antigen, on a permissive background genome.
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