Major Depresif Bozukluk Tanılı 350 Ergen Olgunun Klinik Özellikleri, Hastalık Şiddeti ve Tedavi Seçeneklerinin Değerlendirilmesi: Retrospektif Kesitsel Bir Çalışma

Abstract

Objective: Major Depressive Disorder (MDD) is an important mental health disorder that is common in adolescence. In our study, it was aimed to evaluate depression severity, treatment methods and clinical features of adolescents who were followed up and treated with MDD diagnosis. Methods: Between January and December 2015, 350 adolescent patients between 12-18 years of age who consulted with child and adolescent psychiatry clinic and diagnosed by unipolar MDD according to DSM-5 was reviewed. The sociodemographic and clinical features of these cases were evaluated. SPSS 17.0 was used for statistical evaluation. Results: MDD was diagnosed in 350 (7.5%) of 4,646 adolescents who applied to the outpatient clinic during the 1-year period. Girls were 75.4% of the sample. When the cases were classified in terms of severity of depression, it was found that 45.7% of the whole sample was mild, 44.3% was middle and 10% was severe MDD and the girls were higher in all groups. Pharmacotherapy was applied in 81.7% of the sample, 15.1% of psychotherapies, 3.1% of the combination of pharmacotherapy and psychotherapy. Selective serotonin reuptake inhibitors (SSRIs) alone were preferred in 87.4% of the cases. Somatoform disorder (dissociative and conversion disorder) and bereavement reaction were significant for the combined use of pharmacotherapy and psychotherapy. At least one adverse event was detected in 8.8% of the cases. Discussion: Compatibly the literature, in adolescence MDD diagnosis was significantly more common in females in all severity groups. SSRIs monotherapy is mostly used as the first option in treatment. Our study will contribute to the related literature in terms of involving wide sampling, treatment and severity evaluation in adolescents with MDD; but generalization may not be appropriate because of the the study’s cross-sectional and situation determination nature