Major Culprit Allergen Sensitization Patterns According To Age In Korean Atopic Dermatitis Patients

Abstract

M O N D A Y 677 Racial Differences In The Relationship Of Total and FoodSpecific IgE To Atopic Dermatitis In Childhood Dr. Gillian Bassirpour, MD, Dr. Edward M. Zoratti, MD, FAAAAI, Ganesa Wegienka, PhD, Ms. Suzanne Havstad, M.A., Alexandra Sitarik, MS, Dr. Haejin Kim, MD, Dr. Dennis Ownby, MD, FAAAAI, Dr. Christine Cole Johnson, PhD, MPH, FAAAAI; Division of Allergy and Clinical Immunology, Henry Ford Hospital, Detroit, MI, Henry Ford Health System, Detroit, MI, Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, Department of Pediatrics Georgia Regents University, Augusta, GA. RATIONALE: Elevated IgE is a hallmark of atopic dermatitis (AD). Although AD and elevated IgE are more prevalent in African American (AA) compared to Caucasian (C) children, it is unknown if the relationship between AD and IgE is similar between these groups. METHODS: Data were analyzed from 371 AA and 138 C children in the DetroitWHEALS birth cohort. ADwas defined as current or past physician diagnosis as determined at a study-related encounter at 2-3 years of age. Total and food-specific IgE (sIgE) levels for peanut, egg, and milk were determined. Univariate and multiple logistic regression models, stratified by race of child, were used to assess the association of AD with both total IgE and food sensitization. Food sensitization was included in the model as either the sum of the 3 food sIgEs or, separately, having at least one positive sIgE (>_0.35 kU/L) to food. RESULTS: Elevated total IgEwas independently associatedwith ADonly among Caucasian children [adjusted odds ratio (aOR) 1.81, 95% CI 1.03, 3.15, p5 0.038]. In contrast, the sum of the sIgEs for the foods [aOR 1.46, 95% CI 1.15, 1.86, p 5 0.002] or the presence of >_ 1 positive food sIgE [aOR 2.05, 95% CI 1.09, 3.87, p 5 0.027] was independently associated with AD among AA children only. CONCLUSIONS: The association of IgE to AD differs among AA and C children. Food sIgE is independently linked to AD among AA children. Such an association is not evident in C children after adjustment for total IgE.