Abstract
Several species belonging to the genus Tabernaemontana have been well researched and utilized for their wide-ranging biological activities. A few of the most prominent species include Tabernaemontana divaricata, Tabernaemontana catharinensis, Tabernaemontana crassa, and Tabernaemontana elegans. These species and many others within the genus often display pharmacological importance, which is habitually related to their chemical constituents. The secondary metabolites within the genus have demonstrated huge medicinal potential for the treatment of infections, pain, injuries, and various diseases. Regardless of the indispensable reports and properties displayed by Tabernaemontana spp., there remains a wide variety of plants that are yet to be considered or examined. Thus, an additional inclusive study on species within this genus is essential. The current review aimed to extensively analyze, collate, and describe an updated report of the current literature related to the major alkaloidal components and biological activities of species within the genus Tabernaemontana.
Highlights
The genus Tabernaemontana belonging to the family Apocynaceae was named by a German physician and botanist, J
Tabernaemontana species consists of flowering shrubs and small-medium-sized trees, which habitually grow in the savannahs, rocky outcrops, and forest understories [3]
Nicola et al [9] examined the antioxidant activity of the alkaloidal fraction in the branch and leaf ethanolic extracts of T. catharinensis
Summary
The genus Tabernaemontana belonging to the family Apocynaceae was named by a German physician and botanist, J. The massive potential of countless Tabernaemontana species has led to the investigation of various plant crude extracts, fractionations, chemical constituents, and isolated compounds [2]. The outcomes of the study revealed the presence of major alkaloids, such as 16-epi-affinine, coronaridine-hydroxyindolenine, voachalotine, voacristine-hydroxyindolenine, 12-methoxy-n-methyl-voachalotine, and a derivative of voacristine or voacangine (Table 1) It was suggested by Nicola et al [9] that these chemical constituents exhibited anticholinesterase activity and can be recommended for the future treatment of neurodegenerative disease. According to Mairura [45], a substantial amount of indole alkaloids have been identified and isolated from the stem bark, rootbark, and seeds of T. crassa Major alkaloids include those of the ibogan class, such as coronaridine, monoand di-methoxy derivatives of isovoacangine, conopharyngine, and the aspidospermatanclass apparicine (Table 1). The improvements in science and medicine have allowed the discovery of new properties of extracts, fractionations, and the identification and isolation of novel compounds [2]
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