Major adverse outcomes in patients with acute type A aortic dissection undergoing total arch replacement with frozen elephant trunk procedure

Abstract

BackgroundThe objective of this investigation was to identify the risk factors linked to major adverse outcomes (MAO) subsequent to total arch replacement with frozen elephant trunk procedure (TAR+FET) surgery among patients diagnosed with acute type A aortic dissection (ATAAD). Additionally, the study aimed to elucidate the influence of these adverse outcomes on the long-term prognosis of the patients. Method670 ATAAD patients received the TAR+FET procedure. Multivariable logistic regression was used to investigate the risk factors associated with in-hospital MAO. Additionally, long-term survival outcomes were assessed through follow-up observations of all patients. ResultsThe overall in-hospital mortality was 4.33%. Among 670 patients, 169 patients (25.22%) developed postoperative MAO. Multivariate analysis showed that in-hospital MAO was positively associated with age (OR = 1.025, 95%CI: 1.005–1.045, P = 0.014), lower limb symptoms (OR = 2.562, 95%CI: 1.407–4.666, P = 0.002), involvement of coronary artery (OR = 2.027, 95%CI: 1.312–3.130, P = 0.001), involvement of left renal artery (OR = 1.998, 95%CI: 1.359–2.938, P < 0.001), CPB time (OR = 1.011, 95%CI: 1.007–1.015, P < 0.001) and WBC counts (OR = 1.045, 95%CI: 1.007–1.083, P = 0.019). MAO group showed a worse long-term prognosis than those non-MAO group (P = 0.002). ConclusionsWhile TAR+FET can be an effective treatment option for ATAAD patients, careful patient selection and management are essential in minimizing the risk of MAO and ensuring long-term success.