Major Adverse Cardiovascular Events in Patients Starting Peritoneal Dialysis Based on the CKD-EPI Versus Thai eGFR Equation: A Retrospective Cohort Study

Abstract

Background: Major adverse cardiovascular events (MACE) are the leading cause of deathin chronic kidneydisease (CKD) patients. The relationship between the initiation of peritoneal dialysis (PD) and MACE isunclear.Objective: This study compared the incidence of MACE in PD patients when the estimated- glomerularfiltration rate (eGFR) is calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKDEPI) equation with the Thai eGFR equation.Method: The study was conducted among 684 end-stage CKD patients in a referral hospital in Thailandbetween 2011-2018. The first occurrence of cardiovascular events related MACE was defined as dependentvariable. Logistic regression was used to identify the relationship.Results: The incidence of MACE was different between CKD-EPI group (10.9%) and Thai eGFR group(12.4%). After adjusting for other factors, the PD initiation using eGFR calculated by CKD-EPI equationdid not affect the incidence of MACE when compared to those from Thai eGFR equation (Ajd.OR: 1.11;95%CI: 0.68-1.82, P-value = 0.685).Conclusion: There was no effect on incidence of MACE when PD was initiated based on eGFR calculatedusing the CKD-EPI equation compared with the Thai eGFR equation.