Abstract
BackgroundWe aimed to systematically compare Major Adverse Cardiac Events (MACEs) and mortality following Percutaneous Coronary Intervention (PCI) in patients with and without Chronic Obstructive Pulmonary Diseases (COPD) through a meta-analysis.MethodsElectronic databases (Cochrane library, EMBASE and Medline/PubMed) were searched for English publications comparing in-hospital and long-term MACEs and mortality following PCI in patients with a past medical history of COPD. Statistical analysis was carried out by Revman 5.3 whereby Odds Ratio (OR) and 95% Confidence Intervals (CI) were considered the relevant parameters.ResultsA total number of 72,969 patients were included (7518 patients with COPD and 65,451 patients without COPD). Results of this analysis showed that in-hospital MACEs were significantly higher in the COPD group with OR: 1.40, 95% CI: 1.19–1.65; P = 0.0001, I2 = 0%. Long-term MACEs were still significantly higher in the COPD group with OR: 1.58, 95% CI: 1.38–1.81; P = 0.00001, I2 = 29%. Similarly, in-hospital and long-term mortality were significantly higher in patients with COPD, with OR: 2.25, 95% CI: 1.78–2.85; P = 0.00001, I2 = 0% and OR: 2.22, 95% CI: 1.33–3.71; P = 0.002, I2 = 97% respectively. However, the result for the long-term death was highly heterogeneous.ConclusionSince in-hospital and long-term MACEs and mortality were significantly higher following PCI in patients with versus without COPD, COPD should be considered a risk factor for the development of adverse clinical outcomes following PCI. However, the result for the long-term mortality was highly heterogeneous warranting further analysis.
Highlights
We aimed to systematically compare Major Adverse Cardiac Events (MACEs) and mortality following Percutaneous Coronary Intervention (PCI) in patients with and without Chronic Obstructive Pulmonary Diseases (COPD) through a meta-analysis
Bundhun et al BMC Cardiovascular Disorders (2017) 17:191. In this new era of 2016–2017, where the total number of smokers has increased drastically among the youngsters and the older population of males and females, Chronic Obstructive Pulmonary Diseases (COPD) might soon overcome other major worldwide causes of death [1, 2]. Even though this severe chronic respiratory disease is known from decades, limited data are available on patients who suffer coronary comorbidities and who are candidates for Percutaneous Coronary Intervention (PCI)
Insights from the National Heart, Lung and Blood Institute Dynamic Registry showed COPD to be associated with higher Major Adverse Cardiac Events (MACEs) and mortality rates following PCI [3]
Summary
We aimed to systematically compare Major Adverse Cardiac Events (MACEs) and mortality following Percutaneous Coronary Intervention (PCI) in patients with and without Chronic Obstructive Pulmonary Diseases (COPD) through a meta-analysis In this new era of 2016–2017, where the total number of smokers has increased drastically among the youngsters and the older population of males and females (smoking cigarettes began at a very young age, female smokers are on the rise, and passive smokers are becoming more and more common), Chronic Obstructive Pulmonary Diseases (COPD) might soon overcome other major worldwide causes of death [1, 2].
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