Maintenance olaparib plus bevacizumab (bev) after platinum-based chemotherapy plus bev in patients (pts) with newly diagnosed advanced high-grade ovarian cancer (HGOC): Efficacy by timing of surgery and residual tumor status in the Phase III PAOLA-1 trial

Abstract

Objective:In the PAOLA-1/ENGOT-ov25 (NCT01844986) trial, the addition of the PARP inhibitor olaparib to bevacizumab (BEV) maintenance therapy following first-line platinum-based chemotherapy plus BEV led to a statistically significant progression-free survival (PFS) benefit in patients with advanced high-grade ovarian cancer (HR = 0.59, 95% CI 0.49–0.72) (Ray-Coquard et al. Annals Oncol 2019: abst LBA2_PR). This analysis evaluates olaparib plus BEV efficacy in PAOLA-1 by timing of surgery and presence of residual tumor after surgery.