Abstract
Maintenance of iodine intake
Highlights
Dietary iodine status is routinely assessed by measuring urinary iodine excretion (UI)
Despite the relatively low UI values obtained in the Irish study populations, findings for neonatal TSH assessed over the years 1995-2006 did not exceed 3%, a cut off point indicative of iodine deficiency
Trophoblastic cells expressed both NIS and PDS. 125I uptake in primary cultures from placental tissues was enhanced by individual pregnancy related hormones, hCG and oxytocin, with synergism between hormone combinations
Summary
Dietary iodine status is routinely assessed by measuring urinary iodine excretion (UI). Despite the relatively low UI values obtained in the Irish study populations, findings for neonatal TSH assessed over the years 1995-2006 did not exceed 3%, a cut off point indicative of iodine deficiency. As adequate iodine nutrition for the foetus depends on maternal iodine supply, and on the ability of the placenta to successfully transport iodide to the foetal thyroid for use in thyroid hormone biosynthesis, it is proposed to report on placental uptake and possible storage of iodine as a means of maintaining adequate iodine intake in utero.
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