Abstract
The fasciculus gracilis (FG) of the third cervical spinal cord segment (C 3) of adult rats was aspirated and fresh whole pieces of rat 14-day gestation cervical spinal cord, prelabeled with Phaseolus vulguris leucoagglutinin, immediately placed in the pocket of one-half the operates. One to three months later there were no transplant derived rostro-caudal nerve fibers in the C 1 or C 2 segment of the aspiration-only or aspiration-graft FG. However, the neurons of the nucleus gracilis of the host medulla of the aspiration-only group were significantly atrophied whereas ther neurons of the aspiration-graft group were not statistically different from normal. There were normal numbers of neurons in all groups. Using immunohistochemical double labeling for prelabeled astrocytes with PHAL and GFAP, graft-derived astrocytes were found in the necleus gracilis of the host of the host medulla. These data indicate that the trophic action of spinal graft-derived astrocytes maintained neurons in the medulla of the host nucleus gracilis.
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