Abstract
Hypophysectomy during the second week of gestation resulted in severe follicular involution and degeneration of the corpora lutea (CL). Within 7 days, no progesterone could be detected in the ovarian effluent, and implant sites were the only remaining evidence of pregnancy. Degeneration of the interstitial tissue (1ST) was less evident; although little or no basal 20α-hydroxypregn-4-en-3-one (20α-OH) secretion was measurable, substantial amounts of this steroid (but no progesterone) were secreted following acute LH stimulation. None of the pituitary gonadotrophins (LH, FSH, or prolactin) supported luteal function when administered individually, but each one exerted a specific effect on ovarian structure and function: LH, in doses of 150 or 250 μg/X2 daily sc, depleted 1ST cholesterol and induced ovarian atrophy; FSH, 200-500 μ/X2 daily sc, stimulated follicular growth; and prolactin, 500μg/X2 daily sc, produced 1ST hypertrophy. When prolactin was combined with FSH (either with or without 5-20μg/ of LH), p...
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