Abstract
The communication between different membrane-bounded compartments in the cell is brought about by vesicles. Vesicles are generated from a donor compartment and travel to an acceptor organelle, where they will dock and fuse. Kamena and Spang show that an active mechanism exists in the cell that prevents back-fusion of newly formed vesicles with the donor membrane. This mechanism provides directionality to vesicular transport. In Saccharomyces cerevisiae , the TIP20 protein prevents the back-fusion of endoplasmic reticulum (ER)-derived vesicles and could thus act as a discriminator between incoming and outgoing vesicles at the ER. F. Kamena, A. Spang, Tip20p prohibits back-fusion of COPII vesicles with the endoplasmic reticulum. Science 304 , 286-289 (2004). [Abstract] [Full Text]
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