Abstract
During orthodontic tooth movement (OTM) a remodeling of the periodontal ligament (PDL) and the alveolar bone occurs. We have recently observed that the expression of CGRP and substance P (SP) increases in the PDL and dental pulp in response to buccally directed OTM of the upper first molar in the rat. We have now examined whether there is also an involvement of VIP and NPY in this type of OTM. A sectional arch wire cemented to the upper incisors exerted an orthodontic force, mediated by a coil on the lingual side of the tooth, for 24 hours. It was observed that the blood vessels in the periodontal ligament were supplied with VIP- and NPY-immunoreactive (IR) nerve fibers, whereas VIP-IR nerve fibers in contrast to NPY-IR fibers were only occasionally observed in the dental pulp. No significant changes were observed in response to OTM. The observations suggest that VIP and NPY, in contrast to the main sensory neuropeptides CGRP and SP, are not involved in the tissue processes that occur in the remodeling of PDL and alveolar bone during orthodontic tooth movement.
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