Abstract
In isolated rat heart mitochondria lipid peroxidation was induced with ADP and ferrous sulfate (FeSO 4). Oxygen consumption and malondialdehyde (MDA) production were measured to quantitate lipid peroxidation. The antioxidant effects of magnolol and honokiol purified from Magnolia officinalis were 1000 times higher than that of α-tocopherol. The ic 50 values of magnolol and honokiol for inhibition of oxygen consumption were 8.0 × 10 −8M and 1.0 × 10 −7 M, respectively, while that of α-tocopherol was 1.0 × 10 −4 M. Magnolol at 0.5 μM inhibited 71.4 ± 9.4% of oxygen consumption and 59.3 ± 4.6% MDA production. At the same concentration, honokiol inhibited 78.1 ± 4.7% of oxygen consumption and 86.9 ± 4.0% of MDA production. Of conjugated diene formation 48.4 ± 4.6% and 53.1 ± 3.4% were inhibited by 0.5juM magnolol and honokiol, respectively. Also both magnolol and honokiol exhibited free radical scavenging activities as shown by the diphenyl- p-picrylhydrazyl assay, but they were less potent than α-tocopherol.
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