Magnitude and correlates of cognitive impairment among major depressive disorder patients in Addis Ababa: institution based cross-sectional study

Abebe Ambaw,Getachew Tesfaw Desalegn

doi:10.1186/s13104-019-4184-5

Abebe Ambaw, Getachew Tesfaw Desalegn

Open Access

https://doi.org/10.1186/s13104-019-4184-5

Copy DOI

Journal: BMC research notes	Publication Date: Mar 14, 2019
Citations: 9	License type: open-access

Affiliation: University of Gondar

Abstract

ObjectiveCognitive impairments are now widely recognized and emerging as an important therapeutic target in a patient with a major depressive disorder (MDD). It associated with a more deteriorating course of illness among MDD patients. Therefore, understanding the level of cognitive impairment and associated factors is crucial to provide optimal care for MDD patients.ResultThe proportion of cognitive impairment among MDD patients was found to be 54.4% (95%, CI (49.6, 59.3). Factors significantly associated with having cognitive impairment were age adjusted odds ratio (AOR) = 3.00, 95%, confidence interval (CI): (1.49, 6.03), educational status, (AOR = 5.36, 95% CI 2.16, 13.26), employment status (AOR = 3.63, 95 CI 1.99, 6.62), duration of the illness (AOR = 3.16, 95% CI 1.31, 7.64), having co-morbid psychiatric illnesses (AOR = 2.16, 95% CI 1.26, 3.71), and illness relapse (AOR = 2.97, 95% CI 1.54, 5.73).

Highlights

Major depressive disorder (MDD) is one of the most common mental illnesses with an estimated lifetime prevalence of 16.6%
Clinical and psychosocial characteristics Among the participants, 274 (69.4%) developed MDD after the age of 25 years and three-forth 75.2% had been with the illness for more than 10 years
Prevalence of cognitive impairment This study showed that the prevalence of Cognitive impairment (CI) among study participants was found to be 54.4% with 95% CI (49.6, 59.3)

Summary

Introduction

Major depressive disorder (MDD) is one of the most common mental illnesses with an estimated lifetime prevalence of 16.6%. More than 350 million people estimated to have MDDs globally [1]. The World Health Organization (WHO) Global Burden of Disease study ranked that depression is the most serious disorder in the world for total disability-adjusted years among people in the middle years of life [2]. Major depressive disorders can negatively affect cognitive function and cognitive loss after the onset of illness [3, 4]. Different factors could play a role in the development of CI secondary to depression. These include length of the Cognitive dysfunction is a core component of MDD [9–12]. Almost half of the MDD patients have been affected by CI [14]

Methods

Results

Discussion

Conclusion