Abstract
Magnetic particles are versatile imaging agents that have found wide spread applicability in diagnostic, therapeutic, and rheology applications. In this study, we demonstrate that mechanical waves generated by a localized inclusion of magnetic nanoparticles can be used for assessment of the tissue viscoelastic properties using magnetomotive optical coherence elastography. We show these capabilities in tissue mimicking elastic and viscoelastic phantoms and in biological tissues by measuring the shear wave speed under magnetomotive excitation. Furthermore, we demonstrate the extraction of the complex shear modulus by measuring the shear wave speed at different frequencies and fitting to a Kelvin-Voigt model.
Highlights
Elastography is the image-based mapping of tissue mechanical properties, which is important in many areas of medicine and biology
Elastography based on optical methods such as optical coherence elastography (OCE) has attracted widespread attention in recent years as it can offer much higher spatial resolution and mechanical sensitivity compared to Ultrasound-based elastography (UE) and magnetic resonance elastography (MRE), with the well-known tradeoff of a shallow imaging depth (~1–2 mm) in highly scattering tissues
We show the measurement of the shear wave speed under magnetomotive excitation in tissue mimicking elastic and viscoelastic phantoms and in
Summary
Elastography is the image-based mapping of tissue mechanical properties, which is important in many areas of medicine and biology. The sample is mechanically perturbed and imaging modalities are used to detect the induced displacements, which can subsequently be used to infer the material mechanical properties under certain simplifying assumptions. Elastography techniques differ in the way the sample is mechanically perturbed, how the induced changes are detected, and how the data is processed to assess the material mechanical properties [2]. Elastography based on optical methods such as optical coherence elastography (OCE) has attracted widespread attention in recent years as it can offer much higher spatial resolution and mechanical sensitivity compared to UE and MRE, with the well-known tradeoff of a shallow imaging depth (~1–2 mm) in highly scattering tissues. OCE has been demonstrated using needle based configurations that can access deeper underlying structures [4]
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