Abstract
Mild traumatic brain injury (mTBI) is a leading cause of sustained impairment in military and civilian populations. However, mTBI is difficult to detect using conventional MRI or CT, even in patients with persistent postconcussive symptoms (PCS). Injured brain tissues in mTBI patients generate abnormal slow-waves (1–4 Hz) that can be measured by resting-state magnetoencephalography (MEG). We describe a voxel-based MEG slow-wave imaging approach for detecting abnormality in mTBI patients with persistent PCS on a single-subject basis (Huang et al., Neuroimage Clin 5:109–119, 2014). A normative database from 79 healthy control subjects was established for all brain voxels. High-resolution MEG source magnitude images were obtained by the Fast-VESTAL method (Huang et al., Neuroimage 84:585–604, 2014). In 84 mTBI patients (36 from blasts, and 48 from non-blast causes), this method detected abnormalities with positive detection rates of 84, 86, and 83 % for the combined (blast plus non-blast), blast, and non-blast mTBI groups, respectively, with no false-positives in the control subjects.
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