Magnetoencephalography and High-Density Electroencephalography Study of Acoustic Event Related Potentials in Early Stage of Multiple Sclerosis: A Pilot Study on Cognitive Impairment and Fatigue.

Damiano Paolicelli,Giusy Tancredi,Katia Ricci,Eleonora Gentile,Maria Trojano,Alessia Manni,Marina De Tommaso,Silvia Giovanna Quitadamo,Rosa Gemma Viterbo,Antonio Iaffaldano

doi:10.3390/brainsci11040481

Damiano Paolicelli, Giusy Tancredi + Show 8 more

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https://doi.org/10.3390/brainsci11040481

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Abstract

Cognitive impairment (CI) is a common and disabling symptom of Multiple Sclerosis (MS) with a negative impact on daily living. In this pilot study, we applied magnetoencephalography (MEG) and high density (hd) electroencephalography (EEG) study to evaluate acoustic P300 features in a cohort of early MS. Sixteen MS patients (pwMS) and 19 healthy controls (HCs) matched for age and gender underwent an MEG-/(hd)-EEG-co-recording, using 306-channel Vectorview and 64 scalp electrodes. CI was assessed using Rao’s Brief Repeatable Battery (BRB). Moreover, we performed psychometric tests to assess depression and fatigue. In pwMS, we observed a slight latency prolongation of P300 peak compared to HCs, while P300 amplitude and scalp distribution were similar in the two groups. pwMS did not show an amplitude reduction and different scalp distribution of Event-Related Potentials (ERPs) and Event Related Fields (ERFs) related to an acoustic oddball paradigm. We found an inverse correlation between P300 amplitude and fatigue (r Spearman = −0.4; p = 0.019). In pwMS, phenomena of cortical adaptation to early dysfunction could preserve the cognitive performance of the P300 acoustic task, while the development of fatigue could prospectively lead to amplitude decline of P300, suggesting its possible role as a biomarker.

Highlights

Cognitive impairment (CI) is a common and disabling symptom of Multiple Sclerosis (MS)
CI has been reported in all disease phenotypes, disease duration and age play an important role in the cognitive profile of pwMS [2]
P300 waves, with slight differences in topographical representation, as we demonstrated by employing high resolution topographical analysis, which enabled the detection of different Event-Related Potentials (ERPs)/Event Related Fields (ERFs) scalp distribution

Summary

Introduction

Cognitive impairment (CI) is a common and disabling symptom of Multiple Sclerosis (MS). Its prevalence ranges from 43% to 70% of MS patients (pwMS) [1]. CI has been reported in all disease phenotypes, disease duration and age play an important role in the cognitive profile of pwMS [2]. The prevalence of CI is higher at later stages of relapsing-remitting (RR) MS and in progressive forms of the disease [2,3], but cognitive dysfunctions were detected both in patients with. Isolated Syndrome (CIS) and in the early stages of relapsing forms [4,5]. Some evidences suggested that early CI is a bad prognostic factor being associated with higher risk of conversion to definite MS [7], 4.0/)

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