Abstract
Hypothermia is an effective neuroprotective strategy for acute stroke. However, in clinical practice, the induction of hypothermia is achieved through the systemic reduction of body temperature (using thermal covers or endovascular cooling devices) which results in a complex system associated in many cases to side effects. Therefore, the aim of this study was to test the magnetocaloric effect as a potential new therapeutic strategy for stroke by means of an adiabatic magnetic refrigerator device.As a first approach, we have developed a simple device to evaluate in vitro the thermodynamic behavior of different concentrations of commercial gadolinium powder as a reference magnetocaloric material. The samples, properly thermally insulated, were cyclically magnetized and demagnetized at room temperature by 1T permanent magnets in order to induce an adiabatic magnetic effect. Under the experimental conditions tested, results showed a maximun non-accumulative temperature variation of 0.2°C, insufficient to carry out an effective hypothermia. This study allowed us to discuss about the use of new materials and strategies for further in vivo experiments.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
