Abstract
I read the recent report on magnetization transfer ratio as a marker for myelin in multiple sclerosis with a great interest (1). Vavasour et al concluded that “MTR was correlated with WC in MS tissue, indicating that inflammation and edema influence MTR (1).” This finding is very interesting. However, due to the few subjects, the usefulness of the work might be limited. Indeed, the magnetization transfer ratio is widely mentioned for its usefulness as marker in multiple sclerosis. With the detected limitation, it is interesting to add other parameters from the imaging study to increase the diagnostic property. Further studies on the analysis of other MT parameters, such as magnetization transfer rate (k(for)) and relative measure of water content (T1(free)), will be useful. Ropele et al reported that “Estimates of k(for) and T1(free) appear to complement MTR measurements for the understanding of MT changes that occur with different types of MS abnormalities in the brain (2).” Viroj Wiwanitkit MD*, * Wiwanitkit House Bangkhae, Bangkok, Thailand.
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