Magnetization transfer contrast (MTC)--which is the most MTC-sensitive MRI sequence?

Abstract

This study aimed at evaluating MTC-sensitivity of frequently used MR-sequences. 7 sequences (T1-, T2-, PD-weighted SE, four gradient-echo sequences) were combined with a 4 element on-resonance MT-Pulse at 0.5 Tesla (T5, Philips medical systems). The measurements were performed at a knee joint and MT-ratios of cartilage, muscle, fat and a copper sulfate phantom were calculated. Proton density weighted gradient and to a lesser degree spin-echo sequences were superior to T1- and T2-weighted sequences in visualising the MT effects. It is important to choose an appropriate MR-sequence for MTC experiments. Proton-density gradient echo sequences are recommended for that purpose. T1- and T2-weighted SE sequences should be avoided.