Abstract
Magnetic particle-labeled biomaterial detection has attracted much attention in recent years for a number of reasons; easy manipulation by external magnetic fields, easy functionalization of the surface, and large surface-to-volume ratio, to name but a few. In this review, we report on our recent investigations into the detection of nano-sized magnetic particles. First, the detection by Hall magnetic sensor with lock-in amplifier and alternative magnetic field is summarized. Then, our approach to detect sub-200 nm diameter target magnetic particles via relatively large micoro-sized “columnar particles” by optical microscopy is described. Subsequently, we summarize magnetic particle detection based on optical techniques; one method is based on the scattering of the magnetically-assembled nano-sized magnetic bead chain in rotating magnetic fields and the other one is based on the reflection of magnetic target particles and porous silicon. Finally, we report recent works with reference to more familiar industrial products (such as smartphone-based medical diagnosis systems and magnetic removal of unspecific-binded nano-sized particles, or “magnetic washing”).
Highlights
In recent decades, magnetic particles or magnetic beads have attracted huge attention due to their specific abilities
Our first work relates to the detection of magnetic particle by InSb Hall sensors [3].The method we adopted was inspired by our research into scanning Hall probe microscopy [4,5,6]
We have reviewed our recent results of detecting nano-sized magnetic particles
Summary
Magnetic particles or magnetic beads have attracted huge attention due to their specific abilities. The size of magnetic particles is controllable within the range of a few nano-meters to a few micron meters depending on the desired purpose. Owing to such advantages, magnetic particles are being used in magnetic resonance imaging (MRI), treatment of hyperthermia, drug delivery, cell and biological material manipulation and separation, and several other fields in medical applications [2]. We summarized our recent works related to magnetic detection by magnetic sensors [3,4,5,6,7]. Our recent works connected with industrial products are introduced [14]
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