Abstract
In this study, we have invented a method of delivering drugs deep into articular cartilage with shaped dynamic magnetic fields acting on small metallic magnetic nanoparticles with polyethylene glycol coating and average diameter of 30 nm. It was shown that transport of magnetic nanoparticles through the entire thickness of bovine articular cartilage can be controlled by a combined alternating magnetic field at 100 Hz frequency and static magnetic field of 0.8 tesla (T) generated by 1" dia. x 2" thick permanent magnet. Magnetic nanoparticles transport through bovine articular cartilage samples was investigated at various settings of magnetic field and time durations. Combined application of an alternating magnetic field and the static field gradient resulted in a nearly 50 times increase in magnetic nanoparticles transport in bovine articular cartilage tissue as compared with static field conditions. This method can be applied to locally deliver therapeutic-loaded magnetic nanoparticles deep into articular cartilage to prevent cartilage degeneration and promote cartilage repair in osteoarthritis.
Highlights
There is no accepted medical cure for post-traumatic osteoarthritis (OA)
Magnetic drug delivery was performed for the first time for cartilage tissue in our experiments
Poly Ethylene Glycol (PEG)-coated Magnetic nanoparticles (MNPs) were transported through the entire thickness of cartilage by applying static and alternating magnetic fields simultaneously
Summary
Sagar Chowdhury, et al COLLECTIONS Paper published as part of the special topic on 62nd Annual Conference on Magnetism and Magnetic Materials. Weinberg Weinberg Medical Physics, Inc., 12156 Parklawn Dr, 20852 North Bethesda, Maryland, USA (Presented 7 November 2017; received 22 September 2017; accepted 12 November 2017; published online 29 December 2017)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
