Abstract
A multi-footed composite hydrogel with double responsiveness was prepared by the combination of sodium alginate (SA), gelatin and ferroferric oxide nanomaterials. Under magnetic field control, the multi-footed composite hydrogel could walk and move to the designated locations and release some drugs under the specific environment (pH 7.4) due to the pH sensitivity of SA. The gelatin addition effectively improved the mechanical properties of composite hydrogel, adjusting the drug release behavior of composite hydrogel by the decreased porous structure. Our results demonstrated that the proposed dual stimulus-responsive composite hydrogel could offer a promising choice for medical fixed-point drug release and disease treatment.
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