Abstract
A magnetic solid phase extraction technique followed by liquid chromatography with a fluorescence detector for naproxen analysis in human urine samples was developed. The method includes the extraction of naproxen with a magnetic solid synthetized with magnetite and poly 4-vinylpriridine, followed by the magnetic separation of the solid phase and desorption of the analyte with methanol. Under optimal conditions, the linear range of the calibration curve was 0.05–0.60 μg L−1, with a limit of detection of 0.02 μg L−1. In all cases values of repeatability were lower than 5.0% with recoveries of 99.4 ± 1.3%. Precision and accuracy values are adequate for naproxen (Npx) analysis in urine samples.
Highlights
Naproxen (Npx) is a pharmaceutical compound that belongs to the group of non-steroid anti-inflammatory (AINEs)
Its properties allow it to act as anti-inflammatory, analgesic, and antipyretic [1], it is used for the treatment of rheumatoid arthritis, osteoarthritis, acute traumatic lesion and prophylactic treatment [2]
The aforementioned techniques require a previous sample preparation step because of pharmaceutical compound is found in concentrations of μg L−1 or ng L−1 in different analytical matrices [8,9]
Summary
Naproxen (Npx) is a pharmaceutical compound that belongs to the group of non-steroid anti-inflammatory (AINEs). Its properties allow it to act as anti-inflammatory, analgesic, and antipyretic [1], it is used for the treatment of rheumatoid arthritis, osteoarthritis, acute traumatic lesion and prophylactic treatment [2]. It is a derivative of propionic acid (Figure 1), shows values of log P 3.18 and pKa 4.2. The aforementioned techniques require a previous sample preparation step because of pharmaceutical compound is found in concentrations of μg L−1 or ng L−1 in different analytical matrices [8,9]
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