Magnetic Silica Nanosystems With NIR-Responsive and Redox Reaction Capacity for Drug Delivery and Tumor Therapy

Chengzheng Jia,Keyi Luo,Hang Wu,Shige Wang,Mingxian Huang,Weiju Hao

doi:10.3389/fchem.2020.567652

Abstract

In recent years, more and more researches have focused on tumor photothermal therapy and chemodynamic therapy. In this study, we prepared a multifunctional nanomaterial with potential applications in the above area. The Fe3O4 nanoparticles were synthesized with suitable size and uniformity and then coated with mesoporous silica and polydopamine. The unique core-shell structure not only improves the drug loading of the magnetic nanomaterials, but also produces high photothermal conversion efficiency. Furthermore, the reducibility of polydopamine was found to be able to reduce Fe3+ to Fe2+ and thus promote the production of hydroxyl radicals that can kill the tumor cells based on the Fenton reaction. The magnetic nanomaterials are capable of simultaneously combining photothermal and chemodynamic therapy and permit the efficient treatment for tumors in the future.

Highlights

Cancer is one of the leading causes of death in the world, especially malignant tumors, which poses a great threat to the safety of human life (Siegel et al, 2016)
The transmission electron microscope (TEM) images show that the synthesized monodisperse FMPBs exhibit a porous structure, and a layer of PDA and bovine serum albumin (BSA) was coated on the surface of the nanospheres (Figures S1, S2)
The hydrodynamic dimensions of Fe3O4, Fe3O4@mesoporous silica nanospheres (MSNs), Fe3O4@MSN@PDA, and FMPBs were determined as 167 ± 10.4, 203 ± 7.6, 446 ± 50.9, and 380 ± 34.3 nm, respectively (Figure S3)

Summary

INTRODUCTION

Cancer is one of the leading causes of death in the world, especially malignant tumors, which poses a great threat to the safety of human life (Siegel et al, 2016). More and more functional materials have been introduced into the nanotechnology, and many new treatment methods have emerged, such as photothermal therapy (PTT), magnetocaloric therapy, and chemodynamic therapy (CDT) (Du et al, 2017; Chen et al, 2019; Wu et al, 2019; Zhou et al, 2020). These new treatments have greatly expanded the application of nanocarriers in the treatment of tumors. PDA and bovine serum albumin (BSA) were coated on the outer layer of the material, to form the biocompatible (Hu et al, 2010; Wang et al, 2011) magnetic Fe3O4@MSN@PDA@BSA nanoparticles (defined as FMPBs)

MATERIALS AND METHODS

RESULTS AND DISCUSSION

DATA AVAILABILITY STATEMENT